Abstract: High myopia is an independent risk factor for primary open-angle glaucoma. The prevalence of high myopia in glaucoma is 16%. Optic disc tilt and rotation, choroidal atrophy, lamina cribrosa damage, nerve fiber layer defect and decreased perfusion of optic disc microcirculation in patients with high myopia accelerate the visual field damage of glaucoma and play an important role in the pathogenesis of glaucoma. In clinical work, we should pay close attention to the axial length, central corneal thickness, optic disc morphology, visual field change, retinal nerve fiber layer thickness, intraocular pressure fluctuation and the performance of OCTA in patients with high myopia, and detect early stage of glaucoma patients in high myopia.(Int Rev Ophthalmol, 2020, 44：157-162